ABSTRACT
Objectives: The objective of this study is to find the association between mortality and COVID-19 and risk factors among patients with acute liver injury. Materials and Methods: The research method uses a cross-sectional study design. The participants were COVID-19 patients with acute liver injury admitted in the Field hospital and Somdejphrajaotaksin Maharaj Hospital between 1 March 2020 and 30 September 2021. The data collected included patient's medical history and laboratory results. The analysis used was descriptive statistics and inferential statistics such as chi-square and multiple-logistic regression. Results: The results showed that the number of total participants was 806. Patients with advanced age (more than 60 years) (ORadj = 9.72;95%CI = 4.16-22.12), hypoalbuminemia (≤ 3.5 g/dl) (ORadj = 26.92;95%CI = 6.78-106.87), hepatitis (AST>40 U/L) (ORadj = 5.57;95%CI = 1.91-16.28) and those with a length of hospital stay of at least 7 days (ORadj = 0.13;95%CI = 0.03-0.50) showed a statistically significant association with death. Note that mortality showed the greatest effect size with hypoalbuminemia compared with other variables. The severity of coronavirus infection 2019 (mild, moderate to severe), ALT>40 U/L and ALP>126 U/L. It was found that there was no correlation to mortality with statistically significant. Conclusion: Therefore, the treatment for COVID-19 patients with acute liver injury should be prioritized for high risk patients, especially the elderly, patients with hypoalbuminemia (≤ 3.5 g/dl), hepatitis (AST>40 U/L) and patients with long admission days, relative to other patients, in order to prevent mortality. (Table Presented).